Today's Headlines - 18 August 2023
IITG produces pluripotent stem cells
GS Paper - 3 (Biotechnology)
Researchers from the Indian Institute of Technology Guwahati (IITG) in collaboration with scientists from Christian Medical College, Vellore, have reported a method to convert regular human skin cells into pluripotent stem cells. The human body is made of many kinds of cells – nerve cells, heart cells, liver cells, pancreatic cells, and so on, with unique structures and functions.
More about the News
All these distinctive cells originate from stem cells to perform a specific function. Lack of any of this cell type in a human body will result in a disease or disorder.
Thus, stem cells can be programmed to develop into mature functional cells, which can be used to replace damaged cells.
Stem Cells have to be extracted from embryos or parts of the adult human body like the brain or bone marrow, which is challenging from both ethical and practical aspects.
Thus, scientists are exploring techniques to convert ordinary cells, like skin or blood cells, into pluripotent stem cells – stem cells that can be programmed to develop into any other form of an adult cell type. These cells are called Induced Pluripotent Stem Cells (iPSCs).
The most important advantage of iPSCs is their potential to produce patient-specific cells which can be transplanted to the site of injury or the site of tissue degeneration due to various disease conditions, and thereby, eliminate any chance of immune rejection.
The conversion of mature cells into iPSCs was first shown by Prof. Shinya Yamanaka, who won the Nobel Prize in 2012 for his discovery.
How it Prepared
This research involved introducing specific genes into mature cells to convert them into iPSCs.
The researchers have used a safe, integration-free method, and have introduced genes such as OCT3/4, SOX2, KLF4, L-MYC, LIN28 and a p53 shRNA into skin cells to transform them into iPSCs.
The iPSCs produced by the IITG and CMC researchers were versatile, maintained their genetic makeup well, and could potentially differentiate into a range of body cell types.
Additionally, tests confirmed that the DNA structure of the cells was not altered and matched that of the original cells. Importantly, these iPSCs were found to be free from bacterial contamination.
iPSCs are useful for the design of stem-cell therapies for a range of ailments. iPSCs can be programmed to become beta islet cells to treat diabetes, blood cells to treat leukaemia, or neurons to treat disorders like Parkinson's and Alzheimer’s diseases.
Given the importance and potential of stem cells, the Government of India actively supports stem cell research through the Department of Health Research-Indian Council of Medical Research (DHR-ICMR).
This commitment spans two decades and includes initiatives such as advanced research centres, thematic task forces, and iPSC generation.
The collaboration between IIT Guwahati and CMC Vellore aligns seamlessly with these efforts and India’s endeavour to be at the forefront of stem cell research.
#upsc #news #headline #IITG #pluripotent #stem #cells #biotechnology #technology #guwahati #biotechnology #christian #medical #college #vellore #human #pluripotent #nervecells #pancreaticcells #unique #functions #disease #adult #practical #IPSC #shinyayamanaka #nobelprize #parkinson #alzheimer #diabetes #forces #research #DHR #ICMR #department #taskforces #india
IITG produces pluripotent stem cells
GS Paper - 3 (Biotechnology)
Researchers from the Indian Institute of Technology Guwahati (IITG) in collaboration with scientists from Christian Medical College, Vellore, have reported a method to convert regular human skin cells into pluripotent stem cells. The human body is made of many kinds of cells – nerve cells, heart cells, liver cells, pancreatic cells, and so on, with unique structures and functions.
More about the News
All these distinctive cells originate from stem cells to perform a specific function. Lack of any of this cell type in a human body will result in a disease or disorder.
Thus, stem cells can be programmed to develop into mature functional cells, which can be used to replace damaged cells.
Stem Cells have to be extracted from embryos or parts of the adult human body like the brain or bone marrow, which is challenging from both ethical and practical aspects.
Thus, scientists are exploring techniques to convert ordinary cells, like skin or blood cells, into pluripotent stem cells – stem cells that can be programmed to develop into any other form of an adult cell type. These cells are called Induced Pluripotent Stem Cells (iPSCs).
The most important advantage of iPSCs is their potential to produce patient-specific cells which can be transplanted to the site of injury or the site of tissue degeneration due to various disease conditions, and thereby, eliminate any chance of immune rejection.
The conversion of mature cells into iPSCs was first shown by Prof. Shinya Yamanaka, who won the Nobel Prize in 2012 for his discovery.
How it Prepared
This research involved introducing specific genes into mature cells to convert them into iPSCs.
The researchers have used a safe, integration-free method, and have introduced genes such as OCT3/4, SOX2, KLF4, L-MYC, LIN28 and a p53 shRNA into skin cells to transform them into iPSCs.
The iPSCs produced by the IITG and CMC researchers were versatile, maintained their genetic makeup well, and could potentially differentiate into a range of body cell types.
Additionally, tests confirmed that the DNA structure of the cells was not altered and matched that of the original cells. Importantly, these iPSCs were found to be free from bacterial contamination.
iPSCs are useful for the design of stem-cell therapies for a range of ailments. iPSCs can be programmed to become beta islet cells to treat diabetes, blood cells to treat leukaemia, or neurons to treat disorders like Parkinson's and Alzheimer’s diseases.
Given the importance and potential of stem cells, the Government of India actively supports stem cell research through the Department of Health Research-Indian Council of Medical Research (DHR-ICMR).
This commitment spans two decades and includes initiatives such as advanced research centres, thematic task forces, and iPSC generation.
The collaboration between IIT Guwahati and CMC Vellore aligns seamlessly with these efforts and India’s endeavour to be at the forefront of stem cell research.
#upsc #news #headline #IITG #pluripotent #stem #cells #biotechnology #technology #guwahati #biotechnology #christian #medical #college #vellore #human #pluripotent #nervecells #pancreaticcells #unique #functions #disease #adult #practical #IPSC #shinyayamanaka #nobelprize #parkinson #alzheimer #diabetes #forces #research #DHR #ICMR #department #taskforces #india
Today's Headlines - 10 September 2023
Scientists grew whole model of human embryo
GS Paper - 3 (Biotechnology)
Scientists have successfully grown a “human embryo” in the lab without using an egg or sperm. They used a mix of stem cells — early cells that have the ability to differentiate into other types of cells — that were able to spontaneously assemble into an embryo-like structure, mimicking molecular characteristics of an early embryo.
How was the embryo model created?
The scientists have called it one of the most complete models of a 14-day-old human embryo.
Several teams have been working on developing these human embryo-like models — around six such models have been published this year itself.
None of them fully replicate the processes that happen during the early stages of embryo development, but all of them add to their understanding.
The researchers from Israel used a mix of stem cells and chemicals, a small portion of which was able to spontaneously assemble to form different types of cells that form the foetus, those that provide nutrients to the foetus, cells that lay out the plan for development of the body, and cells that create structures like placenta and umbilical cord to support the foetus.
One of the problems that the team faced, however, was that only 1% of this mixture actually assembled spontaneously, making the process not very efficient.
Why are embryo models and research important?
There is no way for scientists to ethically research the early stages of development of an embryo, as it is difficult to study it after it implants in the uterus. Scientists currently study these initial changes in various lab models or donated embryos.
This research is crucial because the initial days of embryo development is when the majority of miscarriages and birth defects occur.
Studying the initial stages, scientists say, may help understand genetic and inherited diseases better.
The understanding of why some embryos develop normally, retain the proper genetic code, and implant properly in the womb while others do not, may also help in improving success rates of in vitro fertilisation.
Can lab-grown embryos be used to get pregnant?
No. These models are meant to just study the early stages of development of a foetus.
It is generally accepted — and legally supported in most countries — that these embryo models will be destroyed after studying the first 14 days. Attempts to implant are not allowed.
Also, creating a lab-based model that mimics the properties of early embryos is still far from an actual embryo that can implant to the lining of the womb.
#upsc #headline #news #scientists #grew #whole #model #human #embryo #biotechnology #egg #sperm #stem #cells #structure #embryo #mimicking #spontaneously #created #development #israel #chemicals #cells #fortus #placenta #umbilical #cord #body #efficient #research #birth #fertilisation #getpregant #foetus #implant #womb
Scientists grew whole model of human embryo
GS Paper - 3 (Biotechnology)
Scientists have successfully grown a “human embryo” in the lab without using an egg or sperm. They used a mix of stem cells — early cells that have the ability to differentiate into other types of cells — that were able to spontaneously assemble into an embryo-like structure, mimicking molecular characteristics of an early embryo.
How was the embryo model created?
The scientists have called it one of the most complete models of a 14-day-old human embryo.
Several teams have been working on developing these human embryo-like models — around six such models have been published this year itself.
None of them fully replicate the processes that happen during the early stages of embryo development, but all of them add to their understanding.
The researchers from Israel used a mix of stem cells and chemicals, a small portion of which was able to spontaneously assemble to form different types of cells that form the foetus, those that provide nutrients to the foetus, cells that lay out the plan for development of the body, and cells that create structures like placenta and umbilical cord to support the foetus.
One of the problems that the team faced, however, was that only 1% of this mixture actually assembled spontaneously, making the process not very efficient.
Why are embryo models and research important?
There is no way for scientists to ethically research the early stages of development of an embryo, as it is difficult to study it after it implants in the uterus. Scientists currently study these initial changes in various lab models or donated embryos.
This research is crucial because the initial days of embryo development is when the majority of miscarriages and birth defects occur.
Studying the initial stages, scientists say, may help understand genetic and inherited diseases better.
The understanding of why some embryos develop normally, retain the proper genetic code, and implant properly in the womb while others do not, may also help in improving success rates of in vitro fertilisation.
Can lab-grown embryos be used to get pregnant?
No. These models are meant to just study the early stages of development of a foetus.
It is generally accepted — and legally supported in most countries — that these embryo models will be destroyed after studying the first 14 days. Attempts to implant are not allowed.
Also, creating a lab-based model that mimics the properties of early embryos is still far from an actual embryo that can implant to the lining of the womb.
#upsc #headline #news #scientists #grew #whole #model #human #embryo #biotechnology #egg #sperm #stem #cells #structure #embryo #mimicking #spontaneously #created #development #israel #chemicals #cells #fortus #placenta #umbilical #cord #body #efficient #research #birth #fertilisation #getpregant #foetus #implant #womb