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Today's Headlines - 10 September 2023
Scientists grew whole model of human embryo
GS Paper - 3 (Biotechnology)

Scientists have successfully grown a “human embryo” in the lab without using an egg or sperm. They used a mix of stem cells — early cells that have the ability to differentiate into other types of cells — that were able to spontaneously assemble into an embryo-like structure, mimicking molecular characteristics of an early embryo.

How was the embryo model created?

The scientists have called it one of the most complete models of a 14-day-old human embryo.
Several teams have been working on developing these human embryo-like models — around six such models have been published this year itself.
None of them fully replicate the processes that happen during the early stages of embryo development, but all of them add to their understanding.
The researchers from Israel used a mix of stem cells and chemicals, a small portion of which was able to spontaneously assemble to form different types of cells that form the foetus, those that provide nutrients to the foetus, cells that lay out the plan for development of the body, and cells that create structures like placenta and umbilical cord to support the foetus.
One of the problems that the team faced, however, was that only 1% of this mixture actually assembled spontaneously, making the process not very efficient.
Why are embryo models and research important?

There is no way for scientists to ethically research the early stages of development of an embryo, as it is difficult to study it after it implants in the uterus. Scientists currently study these initial changes in various lab models or donated embryos.
This research is crucial because the initial days of embryo development is when the majority of miscarriages and birth defects occur.
Studying the initial stages, scientists say, may help understand genetic and inherited diseases better.
The understanding of why some embryos develop normally, retain the proper genetic code, and implant properly in the womb while others do not, may also help in improving success rates of in vitro fertilisation.
Can lab-grown embryos be used to get pregnant?

No. These models are meant to just study the early stages of development of a foetus.
It is generally accepted — and legally supported in most countries — that these embryo models will be destroyed after studying the first 14 days. Attempts to implant are not allowed.
Also, creating a lab-based model that mimics the properties of early embryos is still far from an actual embryo that can implant to the lining of the womb.

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