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Today's Headlines - 21 July 2023
The ‘good viruses’
fight bacteria
GS Paper - 3 (Health and Diseases)

Scientists now talk of a virome — all the different types of viruses we host in our bodies which contribute to health, much like the bacterial microbiome. This virome is huge. You have 380 trillion virus particles living (or existing) in or on your body right now — 10 times more than the number of bacteria. These viruses lurk in our lungs and blood, live on our skin and linger inside the microbes in our guts. They’re not all bad, however: There are viruses that kill cancer cells and help break down tumors, others that train our immune system and help them fight pathogens, and even some that control gene expression in pregnancy.

Bacteriophages: Anti-bacterial guard dogs

The vast majority of viruses inside us are bacteriophages — viruses that kill bacteria in our microbiomes.
Bacteriophages, also known as phages, are harmless to human cells as they do not recognize them as their bacterial prey.
They work by hunting down bacteria and attaching themselves to the surface of a bacterial cell, before injecting viral DNA material into the cell.
The viral DNA then replicates inside the bacteria, sometimes by borrowing the DNA replication hardware of the bacteria.
Once enough new viruses have been created inside the bacterial cell, the cell then bursts to release the new viral particles.
All this takes just 30 minutes, meaning one virus can become many in a couple of hours.
Phage therapy

The ability of phages to take down bacteria had scientists pondering whether they could be used to treat bacterial infections in the early 20th century, but when antibiotics like penicillin came along, that research faded away.
But antibiotic-resistant strains of bacteria are now on the rise, with experts saying antibiotic resistance is one of the greatest medical challenges facing global communities.
As a result, scientists are racing to find new forms of antibiotic agents, putting phages back on the menu as agents to fight bacterial infections.
The advantages of phages lie in their effectiveness against every multi-resistant pathogen.
Phages are extremely precise in their elimination of bacterial strains — so much so that you don’t disturb the gut microbiome, as is the case with antibiotics.
In theory, then, phages could be a huge boon in our fight against antibacterial resistance.

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