ИБХФ РАН. Новости
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Новостной канал Федерального государственного бюджетного учреждения науки Института биохимической физики им. Н.М. Эмануэля Российской академии наук

Официальный сайт ИБХФ РАН: https://biochemphysics.ru/

Предложить новость: @A_V_Bychkova
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The power of ONE: Immunology in the age of single-cell genomics

🗓 May 25, 2021
6 AM PDT, 9 AM EDT, 2 PM BST, 4 PM IDT

Key Learnings:

How single-cell genomics holds the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways and crosstalk
Learn how recent single-cell genomic studies are changing our perspective of various immune-related pathologies from cancer to autoimmune disease and neurodegeneration
Learn about recent and forthcoming technological and analytical advances in single-cell genomics and their huge potential impact on the future of immunology research and immunotherapy

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#обучение #вебинар #webinar #CurrentProtocols
Watch on demand: Characterising cancer cell states using spatial transcriptomics

Intratumor heterogeneity is a recognized cause of cancer treatment failure. While much of tumor heterogeneity is genetic in nature, recent work using single-cell RNA-Seq has detected a hitherto underappreciated level of transcriptional heterogeneity, leading to the notion of cancer cell states. Studies in melanoma, glioblastoma, and head and neck cancer among others have identified sets of cancer cell states, many of which relate to processes specific to the cell of origin.

Join this virtual seminar to:
Learn about how single-cell RNA-Seq and Spatial Transcriptomics can be integrated
Understand how cell states can be defined using gene modules
Explore how cancer cell states may be related to the tumor microenvironment
Consider the conservation of cancer cell states across diverse cancer types

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#обучение #вебинар #webinar #CurrentProtocols
Catch-up on-demand!

Listen to Dr. Omer Bayraktar of the Wellcome Sanger Institute as he introduces Cell2location, a novel platform for integrating single cell and spatial transcriptomics data.

What you will learn:
▪️ How Cell2location utilizes Bayesian modeling methods to combine single cell RNA-sequencing (scRNA-seq) information with spatial transcriptomic data
▪️ How it creates high-resolution tissue atlases, facilitating a greater understanding of gene expression across cell types present in complex tissues

➡️ Watch

#обучение #вебинар #Webinar #CurrentProtocols
Catch-up on demand

Mass cytometry has emerged in recent years as a powerful tool for single-cell analysis in both basic and clinical research studies.

📍 Michelle Poulin, Manager of North American Field Applications at Fluidigm, will provide a brief introduction of mass cytometry including a technical description of the core technology, cytometry by time-of-flight (used in CyTOF® systems), as well as an overview of the isotopic metal-labeled antibodies and panel kits that enable analysis of over 50 markers per cell.

In this virtual seminar you will learn how the Gaudilliere group is applying mass cytometry and other proteomic technologies to obtain multi-omic views of several clinical scenarios, including:
▪️ immune mechanisms of surgical recovery and complications
▪️ pregnancy and preterm birth
▪️ immune dysfunction and outcomes prediction in patients with COVID-19

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#обучение #вебинар #Webinar #CurrentProtocols