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Epigenetics refers to changes in gene expression that are not caused by changes in the underlying DNA sequence. Instead, epigenetic changes can be caused by modifications to the DNA itself, as well as modifications to the proteins that interact with DNA. These modifications can influence how genes are turned on or off, and can be passed down from one generation to the next.

There are several types of epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA regulation. DNA methylation involves the addition of a methyl group to a cytosine nucleotide in DNA, which can cause the nearby genes to be turned off or silenced. Histone modification involves changes to the proteins around which DNA is wrapped, which can also affect how genes are turned on or off. Non-coding RNA molecules can also play a role in regulating gene expression.

Epigenetic changes can be influenced by a variety of factors, including environmental exposures, diet, stress, and lifestyle choices. These changes can have significant effects on an individual's health and well-being, and may also contribute to the development of various diseases, such as cancer, diabetes, and Alzheimer's disease.

While epigenetic changes are often stable over time, they can also be reversible, which has led to the development of epigenetic therapies as a potential approach to treating various diseases.

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